Category Archives: Optical Imaging

Optical Coherence Tomography OCT
4
Feb

Overview

OCT provides micron scale cross sectional images of tissue microstructure widely used in ophthalmology and intravascular imaging.

Technique

Interferometric detection of backscattered light yields high resolution images. Catheter or probe based delivery adapts OCT to different organs.

Clinical Uses

Retinal layer assessment in ophthalmology and coronary plaque microstructure in cardiology.

Limitations and Safety

Limited penetration depth and need for clear optical window. Specialized probes required.

Photoacoustic Imaging
4
Feb

Overview

Photoacoustic imaging uses pulsed light to generate ultrasound signals from tissue chromophores enabling optical contrast at ultrasound depths.

Technique

Laser excitation and ultrasound detection combine to map hemoglobin oxygenation and targeted contrast agents.

Clinical Uses

Research and emerging clinical applications in oncology vascular imaging and sentinel node mapping.

Limitations and Safety

Limited clinical availability and need for specialized equipment. Regulatory pathways are evolving.

Optical Endoscopy Fluorescence Imaging
4
Feb

Overview

Optical endoscopy with white light and fluorescence enhances mucosal visualization. Targeted fluorescent agents enable molecular imaging during procedures.

Technique

Narrow band imaging autofluorescence and targeted probes increase lesion contrast. Real time visualization guides biopsy and resection.

Clinical Uses

Gastrointestinal and pulmonary endoscopy intraoperative tumor margin assessment and sentinel node mapping.

Limitations and Safety

Agent safety and specificity vary. Interpretation requires training and adjunctive pathology.