Overview

Mn DPDP is a manganese based MRI contrast agent that provided hepatocyte uptake and T1 shortening for liver lesion characterization.

Properties

Manganese acts as a paramagnetic ion producing T1 shortening; agent had partial hepatocellular uptake and biliary excretion.

Uses

Used for liver MRI to improve detection and characterization of focal hepatic lesions when available.

Safety

Use limited by availability and concerns about manganese toxicity in severe hepatic dysfunction; follow regulatory status and local availability.