Overview

Iodine 123 ioflupane is a SPECT radiotracer that binds presynaptic dopamine transporters to assess nigrostriatal integrity.

Properties

I 123 labeled ligand provides high target to background ratio for striatal uptake and is imaged with SPECT cameras several hours after injection.

Uses

Used to support diagnosis of Parkinsonian syndromes versus essential tremor and to evaluate presynaptic dopaminergic neuron loss.

Safety

Administer with thyroid blockade when indicated and follow radiation safety guidelines; consider drug interactions that affect tracer binding.