Overview
Imaging biomarkers quantify tumor characteristics to personalize radiotherapy. Functional imaging such as PET and MRI provides metrics for hypoxia perfusion and cellularity. Biomarkers support dose painting and adaptive strategies.
Imaging Modalities
PET tracers and MRI parametric maps offer complementary biomarker information. Multiparametric approaches improve characterization of tumor heterogeneity. Standardization is required for clinical implementation.
Clinical Trials
Biomarker driven trials evaluate imaging guided dose escalation and adaptive therapy. Imaging endpoints help assess early response and predict outcomes. Collaboration between imaging and radiation oncology is essential.
Implementation Challenges
Reproducibility and harmonization across scanners and sites are major hurdles. Regulatory and reimbursement frameworks influence adoption. Ongoing validation studies aim to demonstrate clinical benefit.